We develop the next generation of antidepressants

Our focus

The Global Challenge of Depression

Major Depression affects at least one in ten people worldwide, inflicting not only devastating individual suffering but also standing as the leading cause of suicides. Depression causes extensive economic damage stemming from treatment costs, work disability, and early retirement.

These facts have prompted INNOVADE Therapeutics to address this challenge by developing groundbreaking solutions for the innovation crisis in the treatment of depression.

Our approach

From neuroscience research...

Science-Driven Innovation in Neuroscience

Backed by a robust and successful academic background and many collaborations worldwide, our team of scientists and researchers has identified novel classes of antidepressants through fundamental neuroscience research.

These medications work by enhancing plasticity and restructuring synapses and networks within the human brain.

Our primary small molecule candidate targets a subunit of specific receptors on inhibitory nerve cells in the brain, resulting in a rapidly effective antidepressant with fewer side effects.

Illustration of a chemical synapse: neurotransmitter release from the presynaptic terminal onto postsynaptic receptors
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... to Drug Development

Our development endeavors encompass a comprehensive platform approach

01

Preclinical Development

Demonstrates efficacy and the mechanism of action in animal models

Illustration: neuronal signalling, electrophysiological recording, NMDA receptor with GluN1A and GluN2D subunits, and brain imaging
02

Preclinical Safety Studies

Ensures compound safety through comprehensive toxicology and pharmacological studies

Illustration: rat and dog, blood sample, liver, kidneys and ECG trace, representing preclinical safety testing
03

Formulation

Develops optimal drug delivery systems and establishes manufacturing processes

Illustration: drug formulation, from powder and particles to tablet press, capsule, tablet and container
04

Clinical Development

Advances therapeutic candidates through clinical trials to validate safety and efficacy in humans

Illustration: physician, clinical trial checklist, capsule and study participants

Our Commitment to Innovation

At INNOVADE Therapeutics, we play a pivotal role in advancing highly innovative, fast-acting, and low-side-effect antidepressant therapy options. Our commitment extends beyond enhancing the quality of life for those affected; we are also dedicated to identifying avenues for exploitation and achieving success in the market. Together, we take a significant step forward to effectively combat the widespread challenge of depression.

Our Team

Upcoming

News & Events

9–11

Nov 2026

Cologne, Germany

We are attending BIO-Europe 2026!

Our team will be in Cologne from the 9th to the 11th of November for this year's event.

Want to connect or schedule a meeting with us during the congress?

10–11

Dec 2026

Marseille, France

We are also attending BioFIT 2026!

Our team will be in Marseille from the 10th to the 11th of December for this year's event.

Want to connect or schedule a meeting with us during the congress?

Featured publication · Nature Communications 2025

A significant part of the scientific foundation behind our approach has been published in Nature Communications, providing peer-reviewed support for GluN2D-containing NMDA receptors as a promising target for rapid antidepressant action.

Vestring S. et al. The NMDA receptor subunit GluN2D is a potential target for rapid antidepressant action. Nat. Commun. 16, 10613 (2025). doi:10.1038/s41467-025-66774-w

Read the publication (PDF)

Interested in the science behind our programs or in exploring potential collaborations?

Contact us

Contact us